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The Ethics Committee at the Ospedale Pediatrico Bambino Gesù, (established in compliance with the Administrative Law dated 08 February 2013, ‘Criteria for the organisation and operating principles of ethics committees') was instated on October 23, 2013. The committee is an independent body not bound by the governing board of the hospital or other authorities, and was developed with individuals from interdisciplinary backgrounds including experts in the fields of healthcare, theology, moral philosophy and bioethics. The committee is nominated by the Board of Directors.

The Ethics Committee, represented by physicians, philosophers, jurists, theologians, statisticians, pharmacologists, pharmacists, bioethics experts, nurses, and patient representatives, provides the following:

- promotes the rights, safety and wellbeing of all those involved in clinical trials, with particular attention to more vulnerable individuals; to this end, the committee reviews, in compliance with best clinical practice standards, the scientific and ethical details of the experimental options offered within the OPBG or by external healthcare specialists, and then provides a binding, written opinion expressing recommendations for the course of action;

- reviews, upon request of the medical staff as well as patients or an individual(s) who represents them, cases or clinical issues connected to the clinical-healthcare treatment provided at the OPBG, and provides unbinding opinions and recommendations; 

- promotes the publishing of documents regarding bioethical issues and guidelines to foster quality improvement in clinical practice, humanize the healthcare institution, and encourage a better understanding of the meaning and approach of healthcare;

- develops and promotes training events on the ethical aspects of biomedical methods and research for both healthcare workers and the general public.